ENCONTRE UM ESPECIALISTA

Tiago Medina
Tiago Medina

Pesquisador Pleno II do Centro Internacional de Pesquisa (CIPE) do A.C.Camargo Cancer Center, orientador no grupo de Imuno-oncologia Translacional e docente do programa de pós-graduação em oncologia do A.C. Camargo Cancer Center.

Formação

Graduação em Biomedicina e mestrado em Agentes Infecciosos e Parasitários na Universidade Federal do Pará (UFPA), doutorado em Imunologia Básica e Aplicada pela Faculdade de Medicina da USP de Ribeirão Preto e Pós-doutorado em Epigenética e Resposta Imune no Princess Margaret Cancer Centre, em Toronto, Canadá.

Contato

Telefone: (11) 2189-5000 - ramal: 2966
E-mail: tiago.medina@accamargo.org.br

Tiago Medina

  • Compreensão dos mecanismos que induzem exaustão de células imunes no microambiente tumoral como forma de identificar alvos imunoterapêuticos
  • Controle da resposta imune tumoral por meio de moduladores epigenéticos

Lima-Fernandes E, Murison A, Medina T, Wang Y, Haynes J, Pollett A, Ma A, Duan S, Zeller C, Leung C, Kreso A, Barsyte-Lovejoy D, Wouters B, Jin J, Carvalho DD, Lupien M, Arrowsmith C, O’Brien CA. Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells. Nat. Commun. 1: 1436 (2019).

Scheer S, Ackloo S, Medina TS, Schapira M, Li F, Ward JA, Lewis AM, Northrop JP, Richardson PL, Kaniskan U, Shen Y, Liu J, Smil D, Mcleod D, Luo M, Jin J, Barsyte-Lovejoy D, Huber KVM, Carvalho DD, Vedadi M, Zaph C, Brown PJ, Arrowsmith CH. A chemical biology toolbox to study protein methyltransferases and epigenetic signaling. Nat Commun. 10: 19 (2019).

Shen SY, Singhania R, Fehringer G, Chakravarthy A, Roehrl MHA, Chadwick D, Zuzarte PC, Borgida A, Wang TT, Li T, Kis O, Zhao Z, Spreafico A, Medina TS, Wang Y, Roulois D, Ettayebi I, Chen Z, Chow S, Murphy T, Arruda A, O’Kane G, Liu J, Mansour M, Mcpherson JD, O’Brien C, Leighl N, Bedard PL, Fleshner N, Liu G, Minden MD, Gallinger S, Goldenberg A, Pugh TJ, Hoffman MM, Bratman SV, Hung RJ, Carvalho DD. Highly sensitive tumor detection and classification using methylome analysis of plasma cell-free DNA. Nature. 563: 579-583 (2018).

Rahul Shinde, Kebria Hezaveh, Marie Jo Halaby, Andreas Kloetgen, Ankur Chakravarthy, Tiago da Silva Medina, Reema Deol, Kieran P. Manion, Yuriy Baglaenko, Maria Eldh, Sara Lamorte, Drew Wallace, Sathi Babu Chodisetti, Buvana Ravishankar, Haiyun Liu, Kapil Chaudhary, David H. Munn, Aristotelis Tsirigos, Michael Madaio, Susanne Gabrielsson, Zahi Touma, Joan Wither, Daniel D. De Carvalho and Tracy L. McGaha. Apoptotic cell–induced AhR activity is required for immunological tolerance and suppression of systemic lupus erythematosus in mice and humans. Nature Immunol. 6: 571-582 (2018). *O artigo é capa da edição de agosto da revista Nature Immunology.

Silva MC, Davoli-Ferreira M, Medina TS, Sesti-Costa R, Silva GK, Lopes CD, Cardozo LE, Gava FN, Lyroni K, Dias FC, Frade AF, Baron M, Nakaya HI, Figueiredo F, Alves-Filho JC, Cunha FQ, Tsatsanis C, Chevillard C, Cunha-Neto E, Hirsch E, Silva JS, Cunha TM. Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis. Nat Commun. 9: 1513 (2018).

Alison Casey, Ankit Sinha, Rajat Singhania, Julie Livingstone, Paul David Waterhouse, Pirashaanthy Tharmapalan, Jennifer Cruickshank, Mona Shehata, Erik Drysdale, Hui Fang, Hyeyeon Kim, Ruth Isserlin, Swneke Bailey, Tiago Medina, Genevieve Deblois, Yu-Jia Shiah, Dalia Barsyte-Lovejoy, Gary D Bader, Mathieu Lupien, Cheryl Arrowsmith, Stefan Knapp, Daniel De Carvalho, Hal Berman, Paul C Boutros, Thomas Kislinger, Rama Khokha. Mammary molecular portraits reveal lineage-specific features and progenitor cell vulnerabilities. J. Cell Biol. 8: 2951-2974 (2018).

Medina TS, Oliveira GG, Silva MC, David BA, Silva GK, Fonseca DM, Sesti-Costa R, Frade AF, Baron MA, Ianni B, Pereira AC, Chevillard C, Cunha-Neto E, Marin-Neto JA, Silva JS. Ebi3 Prevents Trypanosoma cruzi-Induced Myocarditis by Dampening IFN-γ-Driven Inflammation. Front Immunol. 8: 1213 (2017).

Torchia J, Golbourn B, Feng S, Ho KC, Sin-Chan P, Vasiljevic A, Norman JD, Guilhamon P, Garzia L, Agamez NR, Lu M, Chan TS, Picard D, de Antonellis P, Khuong-Quang DA, Planello AC, Zeller C, Barsyte-Lovejoy D, Lafay-Cousin L, Letourneau L, Bourgey M, Yu M, Gendoo DMA, Dzamba M, Barszczyk M, Medina T, Riemenschneider AN, Morrissy AS, […] Dirks PB, Taylor MD, Erdreich-Epstein A, Arrowsmith CH, De Carvalho DD, Rutka JT, Jabado N, Huang A. Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors. Cancer Cell. 30: 891-908 (2016).

Medina Tda S*, Dias FC*, Mendes-Junior CT, Dantas RO, Pissetti CW, Rodrigues Junior V, Dellalibera-Joviliano R, Marin-Neto JA, Gutierrez FR, Moreau P, Silva JS, Donadi EA. Polymorphic sites at the immunoregulatory CTLA-4 gene are associated with chronic chagas disease and its clinical manifestations. PLoS One. 8, e78367 (2013). * These authors contributed equally.

Medina TS, Costa SP, Oliveira MD, Ventura AM, Souza JM, Gomes TF, Vallinoto AC, Póvoa MM, Silva JS, Cunha MG. Increased interleukin-10 and interferon-γ levels in Plasmodium vivax malaria suggest a reciprocal regulation which is not altered by IL-10 gene promoter polymorphism. Malar J. 10, 264 (2011).

Participa destes projetos de pesquisa

Imuno-oncologia translacional